High dose, 1000 mcg methylated folate, as the all natural 6S isomerL-5-MTHF was designed for patients with demonstrated increased need for folate such as those with either the A1298C or C677T MTHFR mutation. It provides 1000 mcg per capsule of folate in the bioidentical, bioactive form, 5-MethylTetraHydroFolate. L-5-MTHF (the "L" signifying that it is the all-natural [6S] isomer) is the active circulating form of folate found in the body and one of the several forms found in food. In nature it is found only as this [6S] isomer, which is why DFH provides 5-MTHF as this natural isomer rather than the mixed (or racemic) form.L-5-MTHF should be used when high doses of folate are needed.Individuals who have tested homozygous with either the A1298C or C677T MTHFR mutation, or those with elevated homocysteine levels, should be using L-5-MTHF as the preferred form of folate supplementation. This will be more effective for them than other forms of folic acid or folates.Others who may benefit from L-5-MTHF:•pregnant women and women wishing to become pregnant who have familial history of depression, high homocysteine levels, or genetic defect in MTHFR. Note: All pregnant women should takePrenatal Pro™ as their comprehensive multivitamin; can combine with L-5-MTHF if higher levels of folate are needed.•women with abnormal pap smears (precancerous)•those with very high homocysteine levels not responding quickly to Homocysteine Supreme™(consider using them together)•dialysis patients•organic acid testing that reveals elevated FIGLU (marker used to identify folate deficiency)•patients with family history of dementia/vascular dementia•patients with depression•long-term alcoholism•long-term use of oral contraceptives, andpersistent use of medications to lower folate levels, including high doses of NSAIDs such as aspirin or ibuprofen; anticonvulsants (phenytoin, phenobarbital, and primidone); trimethoprim (antibiotic), pyrimethamine (antimalarial), triamterene (blood pressure med.) and sulfasalazine (treatment for ulcerative colitis).Do not take 5-MTHF simultaneously with the cholesterol-lowering agents cholestyramine or colestipol because they may decrease the absorption of folate.