HistaEze™ is designed to help support and counteract some of the main symptoms and immune reactions associated with environmental allergies.Key ingredients in this comprehensive allergy support formula include:•Tinofend®, an extract derived from the plant Tinospora cordifolia, and has been used since the early 1900’s in Ayurvedic medicine for its immunomodulating action.•Quercetin, Nettle leaf and Vitamin C, which have been historically used throughout the years to help with the support and management of seasonal allergies.[2,3]•Bicarbonate salts, which were added due to their role as immediate antihistamines, and their ability to mitigate the potential drowsiness experienced by those who may also be taking antihistamine medications.More about Tinofend®Tinofend® contains a proprietary complex of polysaccharides and polyphenols, and has been clinically shown to regulate key immune mediators and stimulate the activity of macrophages.How does it work?Tinofend® addresses the cause of allergies by increasing the number of phagocytic white blood cells, including macrophages, which help consume and rid the body of allergens, and by reducing the number of eosinophils (cells that contain histamine).Supported by researchThe efficacy of Tinospora cordifolia (TC) extract in patients with allergic rhinitis was assessed in a randomized double-blind placebo controlled trial. Seventy-five patients were randomly given either TC or placebo for 8 weeks. They were clinically examined and Hb% (hemoglobin percentage), TLC (total lymphocyte count), DLC (differential lymphocyte count) and nasal smear were performed. At the end of the trial baseline investigations were repeated, drug decoded and results analyzed.With TC treatment, 100% relief was reported from sneezing in 83% patients, in 69% from nasal discharge, in 61% from nasal obstruction and in 71% from nasal pruritus (itching). In the placebo group, there was no relief in 79% from sneezing, in 84.8% from nasal discharge, in 83% from nasal obstruction, and in 88% from nasal pruritus. After TC, eosinophil and neutrophil count decreased and goblet cells were absent in nasal smear.